Longitudinal monitoring of cardiac dysfunction with MRI in a mouse model of obesity and type 2 diabetes

نویسندگان

  • Inès Abdesselam
  • Thomas Troalen
  • Pauline Pepino
  • Anne Dutour
  • Frank Kober
  • Monique Bernard
چکیده

Background Obesity consequences include type 2 diabetes and cardiovascular diseases. Ectopic fat deposition within certain organs such as heart and liver, have recently been shown to be important independent risk factors for the development of these diseases. The purpose of this study was to perform a longitudinal analysis of the changes in cardio-metabolic functions associated with adiposity increase and insulin resistance development.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis

BACKGROUND Diastolic dysfunction is a major cause of morbidity in obese individuals. We aimed to assess the ability of magnetic resonance imaging (MRI) derived left atrial (LA) strain to detect early diastolic dysfunction in individuals with obesity and type 2 diabetes, and to explore the association between cardiac adipose tissue and LA function. METHODS Twenty patients with obesity and T2D ...

متن کامل

HbA1c in Polycystic Ovary Syndrome as the Cardiac Risk Assessment

Objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with hyperandrogenism marked with hirsutism and ovarian dysfunction. These conditions may lead to the risk of insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. These conditions are related to PCOS complications hence our aim was to study and investigate the relationship between high-sens...

متن کامل

Prevalence of Thyroid Autoantibodies in Type 2 Diabetic Patients

OBJECTIVE: Due to the increased prevalence of thyroid dysfunction in subjects with type 2 diabetes and also this fact that antibodies could potentially identify subjects at risk of thyroid dysfunction, this study was conducted to investigate thyroid autoimmunity in type 2 diabetic patients. MATERIAL AND METHODS: Among patients referred to Yazd Diabetes Research Center, 4000 type 2 diabetic pat...

متن کامل

Evaluation of Cardiac Dysfunction in Children and Adolescents with Type 1 Diabetes Mellitus

Background This study was conducted to identify cardiac dysfunction and the relationship of hemoglobin A1c (HbA1c) levels and serum lipids to echocardiographic indices in children and adolescents with T1DM. Materials and Methods: This  case-control study was conducted on  100 cases  including 50 children and adoles...

متن کامل

Effect of Thyroid Dysfunction on Metabolic Response in Type 2 Diabetic Patients

OBJECTIVE: We aimed to evaluate association between thyroid dysfunction, and lipid profile and glycated hemoglobin in type 2 diabetic patients. MATERIALS AND METHODS: This cross-sectional study was carried out in type 2 diabetic patients who referred to Yazd Diabetes Research Center. A total of 1200 type 2 diabetic patients who had thyroid dysfunction according to clinical examinations and lab...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 16  شماره 

صفحات  -

تاریخ انتشار 2014